1. Marques AA, Cesar M, Morais A, Nardi AE, Thuret S, Dias GP. Gender Differences in the Neurobiology of Anxiet y : Focus on Adult Hippocampal Neurogenesis. Neural Plast.2016;2016:1–14.
2. Gale C, Oakley-Browne M. Generalised anxiety disorder. Clinical Evidance Concies 2004. 2004.p. 32–6.
3. Shear MK, Cloitre M, Pine D, Ross J. Anxiety Disorders in Women: Setting a research agenda.Maryland: ADAA; 2005.
4. Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen HU. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States.Int J Methods Psychiatry Res. 2012;21:169–84.
5. Schoenrock SA, Oreper D, Young N, Ervin RB, Bogue A, Valdar W, et al. Ovariectomy results ininbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav. 2016;167:404–12.
6. Mulhall S, Andel R, Anstey KJ. Variation in symptoms of depression and anxiety in midlife women by menopausal status. Maturitas. 2018;108:7–12.
7. Davis SR, Lambrinoudaki I, Lumsden M, Mishra GD, Pal L, Rees M, et al. Menopause. Nat Rev Dis Prim. 2015;1:15004.
8. Rao SS, Singh M, Parkar M, Sugumaran R. Health maintenance for postmenopausal women. AmFam Physician. 2008;78:583–91.
9. Dalal PK, Agarwal M. Postmenopausal Syndrome. Indian J Psychiatry. 2015;57 (Suppl 2):S222–322.
10. Bromberger JT, Kravitz HM, Chang Y, Jr JFR, Avis NE, Gold EB, et al. Does risk for anxiety increase during the menopausal transit ion? Study of Women’s Healt h Across the Nat ion (SWAN).Menopause. 2013;20(5):488–95.
11. Oral A, Unal D, Halici Z, Cadirci E, Sengul O, Ozaltin S, et al. Bilateral Ovariectomy in Young Rats: What Happens in Their Livers during Cecal Ligation and Puncture Induced Sepsis? J Pediatr Adolesc Gynecol. 2012;25(6):371–9.
12. Lagunas N, Calmarza-font I, Diz-chaves Y, Garcia-segura LM. Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress. Horm Behav. 2010;58(5):786–91.
13. de Chaves G, Moretti M, Castro AA, Dagostin W, da Silva GG, Boeck CR, et al. Effects of longterm ovariectomyonanxiety and behavioral despair in rats.Physiol Behav. 2009;97(3–4):420–5.
14. Gleason CE, Dowling NM, Wharton W, Manson JE, Miller VM, Atwood CS, et al. Effects of hormone therapy on cognition and mood in recently postmenopausal women: Findings from the randomized, controlled KEEPS–cognitive and affective study. PLoS Med. 2012;e1001833.
15. Walf AA, Frye CA. Effects of two estradiol regimens on anxiety and depressive behaviors and trophic effects in peripheral tissues in a rodent model. Gend Med. 2009;6(1):300–11.
16. Rodríguez-landa JF, Cueto-escobedo J, Puga-olguín A, Rivadeneyra-domínguez E, Bernal-morales B, Herrera-huerta EV, et al. The phytoestrogen genistein produces similar effects as 17B-estradiol on anxiety-like behavior in rats at 12 weeks after ovariectomy. Biomed Res Int. 2017;2017:1–10.
17. Demetrio FN, Renno, J. J, Gianfaldoni A, Goncalves M, Halbe HW, Filho AH, et al. Effect of estrogen replacement therapy on symptoms of depres- sion and anxiety in non-depressive menopausal women: A randomized double-blind, controlled study. Arch Women’s Ment Heal. 2011;14(6):479 – 486.
18. Tan MN, Kartal M, Guldal D. The effect of physical activity and body mass index on menopausal symptoms in Turkish women: a cross-sectional study in primary care. BMC Womens Health. 2014;14(1):38.
19. Ben J, Soares FMS, Scherer EBS, Cechetti F, Netto CA, Wyse ATS. Running exercise effects on spatial and avoidance tasks in ovariectomized rats. Neurobiol Learn Mem. 2010;94:312–7.
20. Seo J. Treadmill exercise alleviates stress-induced anxiety-like behaviors in rats. J Exerc Rehabil. 2018;14(5):724–30.
21. Merom D, Phongsavan P, Wagner R, Chey T, Marnane C, Steel Z, et al. Promoting walking as an adjunct intervention to group cognitive behavioral therapy for anxiety disorders: a pilot group randomized trial. J Anxiety Disord. 2008;22:959–68.
22. Asmundson GJ, Fetzner MG, Deboer LB, Powers MB, Otto MW, Smit s JA. Let’s get physical: a contemporary review of the anxiolytic effects of exercise for anxiety and its disorders 373. Depress Anxiety. 2013;30:362–73.
23. ACSM. High-Intensity Interval Training. American College of Sports Medicine Leading The Way.ACSM; 2014. p. 1–2.
24. Tschakert G, Hofmann P. High-intensity intermittent exercise: Methodological and physiological aspects. Int J Sports Physiol Perform. 2013;8:600–10.
25. Gibala MJ. High-Intensit y Interval Training : New Insights. Sport Sci Exch. 2007;20:1–6.
26. Gibala MJ, Little JP, Macdonald MJ, Hawley J a. Physiological adaptations to low-volume , high-intensity interval training in health and disease. J Physiol. 2012;5(March):1077–84.
27. Carnevali JC, Eder R, Lira FS, Lima WP, Gonçalves DC, Zanchi NE, et al. Effects of high-intensity intermittent training on carnitine palmitoyl transferase activity in the gastrocnemius muscle of rats. Brazilian J Med Biol Res. 2012;45(8):777–83.
28. Afzalpour ME, Chadorneshin HT, Foadoddini M, Eivari HA. Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain. Physiol Behav. 2015;147:78–83.
29. Wu MH, Lee CP, Hsu SC, Chang CM, Chen CY. Effectiveness of high-intensity interval training on the mental and physical health of people with chronic schizophrenia. Neuropsychiatr Dis Treat. 2015;11:1255–63.
30. Aquina M, Permatasari N. The Effectiveness Of Tofu Liquid Waste As A Natural Phytoestrogen For Mandibular Bone Of Ovariectomized Rats. IDJ. 2012;1:6–13.
31. Kaidah S, Soejono SK, Partadiredja G. Exercise improves hippocampal estrogen and spatial memory of ovariectomized rats. Bratisl Med J. 2016;117(5):94–9.
32. Agustiningsih D, Soejono SK, Soesatyo MHNE, Prakosa D. Exercise induces the synthesis of estrogen in ovariectomized Sprague–Dawley rats ventricular myocardium trough increase expression of CYP19aromatase. Sport Sci Health. 2015;11:337–43.
33. Rauf S, Soejono SK, Partadiredja G. Effects of treadmill exercise training on cerebellar estrogen and estrogen receptors , serum estrogen , and motor coordination performance of ovariectomized rats. IJBMS. 2015;18(6):587–92.
34. Marques-Aleixo I, Oliveira PJ, Moreira PI, Magalhães J, Ascensão A. Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms. Prog Neurobiol. 2012;99:149–62.
35. Terçariol RPG, Godinho AF. Behavioral effects of acute exposure to the insecticide fipronil. Pestic Biochem Physiol. 2011;99:221–5.
36. Field A. Discovering Statistics Using SPSS. Third. London; 2009.
37. Ellison SLR, Barwick VJ, Farrant TJD. Practical Statistics for the Analytical Scientist A Bench Guide. Second. Cambridge: The Royal Society of Chemistry; 2009.
38. Ting AY, Xu J, Stouffer RL. Differential effects of estrogen and progesterone on development of primate secondary follicles in a steroid-depleted milieu in vitro. Hum Reprod. 2015;30(8):1907–17.
39. McLaughlin KJ, Wilson JO, Harman J, Wright RL, A. L, Wieczorek, et al. Chronic 17β-estradiol or cholesterol prevents stress-induced hippocampal CA3 dendritic retraction in ovariectomized female rats: Possible correspondence between CA1 spine properties and spatial acquisition. Hippocampus. 2010;20:768–86.
40. Foster TC. Role of Estrogen Receptor Alpha and Beta Expression and Signalling on Cognitive Function During Aging. Hippocampus. 2012;22(4):656–69.
41. Fuchs T. Menopause and the mind: the effects of menopause and hormone replacement therapy.
MSJA. 2011;3(1):27–30.
42. Mansour SZ, Moustafa EM, Hassan AA, Thabet NM. Protective role of krill oil against estrogen
deficiency induced neurodegeneration in ovariectomized rats. Indian J Exp Biol. 2017;55(5):279–85.
43. Hao L, Wang Y, Duan Y. Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment. Eur J Appl Physiol. 2010;109:879–86.
44. Lu J, Xu Y, Hu W, Gao Y, Ni X, Sheng H, et al. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neurosci Lett. 2014;573:13–8.
45. Marosi K, Mattson MP. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab. 2014;25(2):89–98.
46. Pighon A, Gutkowska J, Jankowski M, Rabasa-Lhoret R, Lavoie JM. Exercise training in ovariectomized rats stimulates estrogenic-like effects on expression of genes involved in lipid accumulation and subclinical inflammation in liver. Metabolism. 2011;60:629–639.
47. Yoelvis G-M, Pareja-Galeano H, Revilla VB-CS, Gomez-Cabrera MC, Gambini J, Gimenez-Llort L, et al. Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms. 2014;45:154–66.
48. Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, et al. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol. 2010;298(November 2009):R372–7.
49. de Almeida AA, da Silva SG, Fernandes J, Peixinho-pena LF, Scorca FA, Cavalheiro EA, et al.Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development. Neurosci Lett. 2013;553:1–6.
50. Al-Rahbi B, Zakaria R, Othman Z, Hassan A, Ahmad AH. Enhancement of BDNF concentration and restoration of the hypothalamic-pituitary-adrenal axis accompany reduced depressive-like behaviour in stressed ovariectomised rats treated with either tualang honey or estrogen. Sci World J. Hindawi Publishing Corporation; 2014;2014:1–8.
2. Gale C, Oakley-Browne M. Generalised anxiety disorder. Clinical Evidance Concies 2004. 2004.p. 32–6.
3. Shear MK, Cloitre M, Pine D, Ross J. Anxiety Disorders in Women: Setting a research agenda.Maryland: ADAA; 2005.
4. Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen HU. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States.Int J Methods Psychiatry Res. 2012;21:169–84.
5. Schoenrock SA, Oreper D, Young N, Ervin RB, Bogue A, Valdar W, et al. Ovariectomy results ininbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav. 2016;167:404–12.
6. Mulhall S, Andel R, Anstey KJ. Variation in symptoms of depression and anxiety in midlife women by menopausal status. Maturitas. 2018;108:7–12.
7. Davis SR, Lambrinoudaki I, Lumsden M, Mishra GD, Pal L, Rees M, et al. Menopause. Nat Rev Dis Prim. 2015;1:15004.
8. Rao SS, Singh M, Parkar M, Sugumaran R. Health maintenance for postmenopausal women. AmFam Physician. 2008;78:583–91.
9. Dalal PK, Agarwal M. Postmenopausal Syndrome. Indian J Psychiatry. 2015;57 (Suppl 2):S222–322.
10. Bromberger JT, Kravitz HM, Chang Y, Jr JFR, Avis NE, Gold EB, et al. Does risk for anxiety increase during the menopausal transit ion? Study of Women’s Healt h Across the Nat ion (SWAN).Menopause. 2013;20(5):488–95.
11. Oral A, Unal D, Halici Z, Cadirci E, Sengul O, Ozaltin S, et al. Bilateral Ovariectomy in Young Rats: What Happens in Their Livers during Cecal Ligation and Puncture Induced Sepsis? J Pediatr Adolesc Gynecol. 2012;25(6):371–9.
12. Lagunas N, Calmarza-font I, Diz-chaves Y, Garcia-segura LM. Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress. Horm Behav. 2010;58(5):786–91.
13. de Chaves G, Moretti M, Castro AA, Dagostin W, da Silva GG, Boeck CR, et al. Effects of longterm ovariectomyonanxiety and behavioral despair in rats.Physiol Behav. 2009;97(3–4):420–5.
14. Gleason CE, Dowling NM, Wharton W, Manson JE, Miller VM, Atwood CS, et al. Effects of hormone therapy on cognition and mood in recently postmenopausal women: Findings from the randomized, controlled KEEPS–cognitive and affective study. PLoS Med. 2012;e1001833.
15. Walf AA, Frye CA. Effects of two estradiol regimens on anxiety and depressive behaviors and trophic effects in peripheral tissues in a rodent model. Gend Med. 2009;6(1):300–11.
16. Rodríguez-landa JF, Cueto-escobedo J, Puga-olguín A, Rivadeneyra-domínguez E, Bernal-morales B, Herrera-huerta EV, et al. The phytoestrogen genistein produces similar effects as 17B-estradiol on anxiety-like behavior in rats at 12 weeks after ovariectomy. Biomed Res Int. 2017;2017:1–10.
17. Demetrio FN, Renno, J. J, Gianfaldoni A, Goncalves M, Halbe HW, Filho AH, et al. Effect of estrogen replacement therapy on symptoms of depres- sion and anxiety in non-depressive menopausal women: A randomized double-blind, controlled study. Arch Women’s Ment Heal. 2011;14(6):479 – 486.
18. Tan MN, Kartal M, Guldal D. The effect of physical activity and body mass index on menopausal symptoms in Turkish women: a cross-sectional study in primary care. BMC Womens Health. 2014;14(1):38.
19. Ben J, Soares FMS, Scherer EBS, Cechetti F, Netto CA, Wyse ATS. Running exercise effects on spatial and avoidance tasks in ovariectomized rats. Neurobiol Learn Mem. 2010;94:312–7.
20. Seo J. Treadmill exercise alleviates stress-induced anxiety-like behaviors in rats. J Exerc Rehabil. 2018;14(5):724–30.
21. Merom D, Phongsavan P, Wagner R, Chey T, Marnane C, Steel Z, et al. Promoting walking as an adjunct intervention to group cognitive behavioral therapy for anxiety disorders: a pilot group randomized trial. J Anxiety Disord. 2008;22:959–68.
22. Asmundson GJ, Fetzner MG, Deboer LB, Powers MB, Otto MW, Smit s JA. Let’s get physical: a contemporary review of the anxiolytic effects of exercise for anxiety and its disorders 373. Depress Anxiety. 2013;30:362–73.
23. ACSM. High-Intensity Interval Training. American College of Sports Medicine Leading The Way.ACSM; 2014. p. 1–2.
24. Tschakert G, Hofmann P. High-intensity intermittent exercise: Methodological and physiological aspects. Int J Sports Physiol Perform. 2013;8:600–10.
25. Gibala MJ. High-Intensit y Interval Training : New Insights. Sport Sci Exch. 2007;20:1–6.
26. Gibala MJ, Little JP, Macdonald MJ, Hawley J a. Physiological adaptations to low-volume , high-intensity interval training in health and disease. J Physiol. 2012;5(March):1077–84.
27. Carnevali JC, Eder R, Lira FS, Lima WP, Gonçalves DC, Zanchi NE, et al. Effects of high-intensity intermittent training on carnitine palmitoyl transferase activity in the gastrocnemius muscle of rats. Brazilian J Med Biol Res. 2012;45(8):777–83.
28. Afzalpour ME, Chadorneshin HT, Foadoddini M, Eivari HA. Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain. Physiol Behav. 2015;147:78–83.
29. Wu MH, Lee CP, Hsu SC, Chang CM, Chen CY. Effectiveness of high-intensity interval training on the mental and physical health of people with chronic schizophrenia. Neuropsychiatr Dis Treat. 2015;11:1255–63.
30. Aquina M, Permatasari N. The Effectiveness Of Tofu Liquid Waste As A Natural Phytoestrogen For Mandibular Bone Of Ovariectomized Rats. IDJ. 2012;1:6–13.
31. Kaidah S, Soejono SK, Partadiredja G. Exercise improves hippocampal estrogen and spatial memory of ovariectomized rats. Bratisl Med J. 2016;117(5):94–9.
32. Agustiningsih D, Soejono SK, Soesatyo MHNE, Prakosa D. Exercise induces the synthesis of estrogen in ovariectomized Sprague–Dawley rats ventricular myocardium trough increase expression of CYP19aromatase. Sport Sci Health. 2015;11:337–43.
33. Rauf S, Soejono SK, Partadiredja G. Effects of treadmill exercise training on cerebellar estrogen and estrogen receptors , serum estrogen , and motor coordination performance of ovariectomized rats. IJBMS. 2015;18(6):587–92.
34. Marques-Aleixo I, Oliveira PJ, Moreira PI, Magalhães J, Ascensão A. Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms. Prog Neurobiol. 2012;99:149–62.
35. Terçariol RPG, Godinho AF. Behavioral effects of acute exposure to the insecticide fipronil. Pestic Biochem Physiol. 2011;99:221–5.
36. Field A. Discovering Statistics Using SPSS. Third. London; 2009.
37. Ellison SLR, Barwick VJ, Farrant TJD. Practical Statistics for the Analytical Scientist A Bench Guide. Second. Cambridge: The Royal Society of Chemistry; 2009.
38. Ting AY, Xu J, Stouffer RL. Differential effects of estrogen and progesterone on development of primate secondary follicles in a steroid-depleted milieu in vitro. Hum Reprod. 2015;30(8):1907–17.
39. McLaughlin KJ, Wilson JO, Harman J, Wright RL, A. L, Wieczorek, et al. Chronic 17β-estradiol or cholesterol prevents stress-induced hippocampal CA3 dendritic retraction in ovariectomized female rats: Possible correspondence between CA1 spine properties and spatial acquisition. Hippocampus. 2010;20:768–86.
40. Foster TC. Role of Estrogen Receptor Alpha and Beta Expression and Signalling on Cognitive Function During Aging. Hippocampus. 2012;22(4):656–69.
41. Fuchs T. Menopause and the mind: the effects of menopause and hormone replacement therapy.
MSJA. 2011;3(1):27–30.
42. Mansour SZ, Moustafa EM, Hassan AA, Thabet NM. Protective role of krill oil against estrogen
deficiency induced neurodegeneration in ovariectomized rats. Indian J Exp Biol. 2017;55(5):279–85.
43. Hao L, Wang Y, Duan Y. Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment. Eur J Appl Physiol. 2010;109:879–86.
44. Lu J, Xu Y, Hu W, Gao Y, Ni X, Sheng H, et al. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neurosci Lett. 2014;573:13–8.
45. Marosi K, Mattson MP. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab. 2014;25(2):89–98.
46. Pighon A, Gutkowska J, Jankowski M, Rabasa-Lhoret R, Lavoie JM. Exercise training in ovariectomized rats stimulates estrogenic-like effects on expression of genes involved in lipid accumulation and subclinical inflammation in liver. Metabolism. 2011;60:629–639.
47. Yoelvis G-M, Pareja-Galeano H, Revilla VB-CS, Gomez-Cabrera MC, Gambini J, Gimenez-Llort L, et al. Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms. 2014;45:154–66.
48. Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, et al. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol. 2010;298(November 2009):R372–7.
49. de Almeida AA, da Silva SG, Fernandes J, Peixinho-pena LF, Scorca FA, Cavalheiro EA, et al.Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development. Neurosci Lett. 2013;553:1–6.
50. Al-Rahbi B, Zakaria R, Othman Z, Hassan A, Ahmad AH. Enhancement of BDNF concentration and restoration of the hypothalamic-pituitary-adrenal axis accompany reduced depressive-like behaviour in stressed ovariectomised rats treated with either tualang honey or estrogen. Sci World J. Hindawi Publishing Corporation; 2014;2014:1–8.
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Affiliations
Saidah Rauf
Program Studi Keperawatan Masohi Poltekkes Kemenkes Maluku
How to Cite
1.
Rauf S. PENURUNNYA KECEMASAN TIKUS OVARIEKTOMI SETELAH LATIHAN INVERVAL DENGAN INTENSITAS TINGGI [Internet]. Jurnal Kesehatan Terpadu (Integrated Health Journal) [Internet]. 4Feb.2019 [cited 2Nov.2025];9(2):1-. Available from: https://www.jurnalpoltekkesmaluku.com/index.php/JKT/article/view/15
PENURUNNYA KECEMASAN TIKUS OVARIEKTOMI SETELAH LATIHAN INVERVAL DENGAN INTENSITAS TINGGI
Kesehatan Terpadu
Vol 9 No 2 (2018): Jurnal Kesehatan Terpadu (Integrated Health Journal) November 2018
Submitted: Feb 4, 2019
Published: Feb 4, 2019
Abstract
It is well established that a decrease of estrogen during natural or surgical menopause (ovariectomy)
could influence female anxiety behaviour both in human and animal experiments. Several studies have
proved that exercise act as a potential therapy to reduce depression and anxiety behaviours. The current
study analyzed the effects of High-Intensity Interval Exercise (HIIE) to anxiety-related behaviours of
rats after long-term ovaries removal. Fifteen Sprague-Dawley rats (twelve weeks old) were used in this
study. All rats were divided into sham-operated, ovariectomy, and ovariectomy with HIIE (OVX
HIIE). The HIIE group was treated for 7 weeks of interval exercise that started after twelve weeks of
ovariectomized using treadmill. Anxiety related behaviour were represented by frequencies to
entrances centre arena, freezing and grooming duration on open field test. A significant decrease
(p<0.05) in the frequencies to enter open arena was detected in ovariectomized rats compared to sham
and ovariectomy with HIIE, while reversed effect has observed in freezing duration. The present results
show that HIIE may help to counteract the ovariectomized effect on anxiety-related behaviours of rats.
The HIIE may become the promising therapy to treat anxiety behaviour on menopause condition.
Keywords: Anxiety, interval exercise, ovariectomy, menopause